• 靶点：
• RERG

• 基因名称：
• RERG

• 蛋白名称：
• Ras-related and estrogen-regulated growth inhibitor

• Human Gene Id：
• 85004

• Human Swiss Prot No：
• Q96A58

• Mouse Gene Id：
• 232441

• Mouse Swiss Prot No：
• Q8R367

• 免疫原：
• Synthesized peptide derived from RERG . at AA range: 70-150

• 特异性：
• RERG Polyclonal Antibody detects endogenous levels of RERG protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• RERG;Ras-related and estrogen-regulated growth inhibitor

• 分子量：
• 23kD

• 背景：
• RERG, a member of the RAS superfamily of GTPases, inhibits cell proliferation and tumor formation (Finlin et al., 2001 [PubMed 11533059]).[supplied by OMIM, Mar 2009],

• 功能：
• disease:Loss of RERG expression may contribute to tumorigenesis in breast. RERG expression is decreased or lost in a significant proportion of primary breast tumors with poor clinical prognosis. High expression of RERG correlates with long relapse-free survival times.,function:Binds GDP/GTP and possesses intrinsic GTPase activity. Has higher affinity for GDP than for GTP. In cell lines overexpression leads to a reduction in the rate of proliferation, colony formation and in tumorigenic potential.,induction:Up-regulated by estradiol. Down-regulated by tamoxifen.,similarity:Belongs to the small GTPase superfamily. Ras family.,tissue specificity:Detected in heart, brain, placenta, lung, liver, skin, kidney and pancreas. Detected in estrogen receptor-positive breast-derived cell lines, but not in estrogen receptor-negative cell lines.,

• 细胞定位：
• Cytoplasm .

• 组织表达：
• Detected in heart, brain, placenta, lung, liver, skin, kidney and pancreas. Detected in estrogen receptor-positive breast-derived cell lines, but not in estrogen receptor-negative cell lines. Expression is decreased or lost in a significant proportion of primary breast tumors with poor clinical prognosis.

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