• 靶点：
• RASSF2

• 简介：
• >>Hippo signaling pathway - multiple species

• 基因名称：
• RASSF2

• 蛋白名称：
• Ras association domain-containing protein 2

• Human Gene Id：
• 9770

• Human Swiss Prot No：
• P50749

• Mouse Gene Id：
• 215653

• Mouse Swiss Prot No：
• Q8BMS9

• Rat Gene Id：
• 311437

• Rat Swiss Prot No：
• Q3B7D5

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human RASSF2. AA range:109-158

• 特异性：
• RASSF2 Polyclonal Antibody detects endogenous levels of RASSF2 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000;IHC 1:50-300

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• RASSF2;KIAA0168;Ras association domain-containing protein 2

• 实测条带：
• 36kD

• 背景：
• This gene encodes a protein that contains a Ras association domain. Similar to its cattle and sheep counterparts, this gene is located near the prion gene. Two alternatively spliced transcripts encoding the same isoform have been reported. [provided by RefSeq, Jul 2008],

• 功能：
• function:Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest.,similarity:Contains 1 Ras-associating domain.,similarity:Contains 1 SARAH domain.,subunit:Interacts directly with activated KRAS in a GTP-dependent manner.,tissue specificity:Widely expressed with highest levels in brain, placenta, peripheral blood and lung. Frequently down-regulated in lung tumor cell lines.,

• 细胞定位：
• Nucleus. Cytoplasm. Chromosome, centromere, kinetochore . Translocates to the cytoplasm in the presence of STK3/MST2 AND STK4/MST1.

• 组织表达：
• Widely expressed with highest levels in brain, placenta, peripheral blood and lung. Frequently down-regulated in lung tumor cell lines.

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