• 靶点：
• PP2A-Aβ

• 简介：
• >>mRNA surveillance pathway;>>Sphingolipid signaling pathway;>>Oocyte meiosis;>>PI3K-Akt signaling pathway;>>AMPK signaling pathway;>>Adrenergic signaling in cardiomyocytes;>>TGF-beta signaling pathway;>>Hippo signaling pathway;>>Tight junction;>>Dopaminergic synapse;>>Long-term depression;>>Chagas disease;>>Hepatitis C;>>Human papillomavirus infection

• 基因名称：
• PPP2R1B

• 蛋白名称：
• Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

• Human Gene Id：
• 5519

• Human Swiss Prot No：
• P30154

• Mouse Gene Id：
• 73699

• Mouse Swiss Prot No：
• Q7TNP2

• Rat Gene Id：
• 315648

• Rat Swiss Prot No：
• Q4QQT4

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human PPP2R1B. AA range:552-601

• 特异性：
• PP2A-Aβ Polyclonal Antibody detects endogenous levels of PP2A-Aβ protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000.IHC:1:50-300 ELISA: 1:20000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• PPP2R1B;Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform;PP2A subunit A isoform PR65-beta;PP2A subunit A isoform R1-beta

• 实测条带：
• 66kD

• 背景：
• This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Mutations in this gene have been associated with some lung and colon cancers. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010],

• 功能：
• disease:Defects in PPP2R1B might be a cause of some lung and colorectal cancers.,domain:Each HEAT repeat appears to consist of two alpha helices joined by a hydrophilic region, the intrarepeat loop. The repeat units may be arranged laterally to form a rod-like structure.,function:The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit.,sequence caution:Contaminating sequence. Sequence of unknown origin in the N-terminal part.,similarity:Belongs to the phosphatase 2A regulatory subunit A family.,similarity:Contains 15 HEAT repeats.,subunit:PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate wi

• 细胞定位：
• membrane raft,extracellular exosome,

• 组织表达：
• Testis,

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