• 靶点：
• MLK1

• 基因名称：
• MAP3K9

• 蛋白名称：
• Mitogen-activated protein kinase kinase kinase 9

• Human Gene Id：
• 4293

• Human Swiss Prot No：
• P80192

• Mouse Gene Id：
• 338372

• Mouse Swiss Prot No：
• Q3U1V8

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human MAP3K9. AA range:561-610

• 特异性：
• MLK1 Polyclonal Antibody detects endogenous levels of MLK1 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• MAP3K9;MLK1;PRKE1;Mitogen-activated protein kinase kinase kinase 9;Mixed lineage kinase 1

• 分子量：
• 122kD

• 背景：
• MAP3K9 (Mitogen-Activated Protein Kinase Kinase Kinase 9) is a Protein Coding gene. Diseases associated with MAP3K9 include retroperitoneal neuroblastoma. Among its related pathways are MAP Kinase Signaling andTGF-Beta Pathway. GO annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is KSR1.

• 功能：
• catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Homodimerization via the leucine zipper domains is required for autophosphorylation and subsequent activation.,function:Activates the JUN N-terminal pathway.,PTM:Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation. Thr-312 is likely to be the main autophosphorylation site.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH3 domain.,subunit:Homodimer.,tissue specificity:Expressed in epithelial tumor cell lines of colonic, breast and esophageal origin.,

• 细胞定位：
• intracellular,integral component of membrane,

• 组织表达：
• Expressed in epithelial tumor cell lines of colonic, breast and esophageal origin.

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