Internexin-α Polyclonal Antibody
- 货号：YT2374
- 应用：WB;IHC
- 种属：Human;Mouse;Rat
- 免疫原：
- Synthesized peptide derived from the Internal region of human Internexin-α.
- 特异性：
- Internexin-α Polyclonal Antibody detects endogenous levels of Internexin-α protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- WB 1:500-2000;IHC 1:50-300
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- INA;NEF5;Alpha-internexin;Alpha-Inx;66 kDa neurofilament protein;NF-66;Neurofilament-66;Neurofilament 5
- 背景：
- Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene is a member of the intermediate filament family and is involved in the morphogenesis of neurons. [provided by RefSeq, Jun 2009],
- 功能：
- developmental stage:Expressed in brain as early as the 16th week of gestation, and increased rapidly and reached a steady state level by the 18th week of gestation.,function:Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NF-L to form the filamentous backbone to which NF-M and NF-H attach to form the cross-bridges.,PTM:O-glycosylated.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the intermediate filament family.,tissue specificity:Found predominantly in adult CNS.,
- 细胞定位：
- extracellular space,nucleoplasm,neurofilament,nuclear membrane,cytoplasmic ribonucleoprotein granule,myelin sheath,intermediate filament cytoskeleton,
- 组织表达：
- Found predominantly in adult CNS.
- Immunohistochemical analysis of paraffin-embedded human Gastric adenocarcinoma. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
