• 靶点：
• GABAA Rα6

• 简介：
• >>Neuroactive ligand-receptor interaction;>>Retrograde endocannabinoid signaling;>>GABAergic synapse;>>Taste transduction;>>Morphine addiction;>>Nicotine addiction

• 基因名称：
• GABRA6

• 蛋白名称：
• Gamma-aminobutyric acid receptor subunit alpha-6

• Human Gene Id：
• 2559

• Human Swiss Prot No：
• Q16445

• Mouse Gene Id：
• 14399

• Mouse Swiss Prot No：
• P16305

• Rat Gene Id：
• 29708

• Rat Swiss Prot No：
• P30191

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human GABRA6. AA range:61-110

• 特异性：
• GABAA Rα6 Polyclonal Antibody detects endogenous levels of GABAA Rα6 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• GABRA6;Gamma-aminobutyric acid receptor subunit alpha-6;GABA(A) receptor subunit alpha-6

• 实测条带：
• 51kD

• 背景：
• GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. [provided by RefSeq, Jul 2008],

• 功能：
• function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.,online information:Forbidden fruit - Issue 56 of March 2005,similarity:Belongs to the ligand-gated ionic channel (TC 1.A.9) family.,subunit:Binds UBQLN1 (By similarity). Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.,

• 细胞定位：
• Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

• 组织表达：
• Cerebellum,

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