• 靶点：
• C9

• 简介：
• >>Complement and coagulation cascades;>>Prion disease;>>Amoebiasis;>>Coronavirus disease - COVID-19;>>Systemic lupus erythematosus

• 基因名称：
• C9

• 蛋白名称：
• Complement component C9

• Human Gene Id：
• 735

• Human Swiss Prot No：
• P02748

• Mouse Swiss Prot No：
• P06683

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human C9. AA range:181-230

• 特异性：
• C9 Polyclonal Antibody detects endogenous levels of C9 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• C9;Complement component C9

• 实测条带：
• 70kD

• 背景：
• This gene encodes the final component of the complement system. It participates in the formation of the Membrane Attack Complex (MAC). The MAC assembles on bacterial membranes to form a pore, permitting disruption of bacterial membrane organization. Mutations in this gene cause component C9 deficiency. [provided by RefSeq, Feb 2009],

• 功能：
• disease:Defects in C9 are a cause of component C9 deficiency (C9D) [MIM:120940]. Patients with C9D suffer from recurrent bacterial infections, predominantly from Neisseria meningitidis.,function:C9 is the final component of the complement system to be added in the assembly of the membrane attack complex. It is able to enter lipid bilayers, forming transmembrane channels.,online information:C9 mutation db,PTM:Thrombin cleaves factor C9 to produce C9a and C9b.,similarity:Belongs to the complement C6/C7/C8/C9 family.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 LDL-receptor class A domain.,similarity:Contains 1 MACPF domain.,similarity:Contains 1 TSP type-1 domain.,

• 细胞定位：
• Secreted . Target cell membrane ; Multi-pass membrane protein . Secreted as soluble monomer. Oligomerizes at target membranes, forming a pre-pore. A conformation change then leads to the formation of a 100 Angstrom diameter pore. .

• 组织表达：
• Plasma (at protein level).

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