• 靶点：
• C6

• 简介：
• >>Complement and coagulation cascades;>>Prion disease;>>Coronavirus disease - COVID-19;>>Systemic lupus erythematosus

• 基因名称：
• C6

• 蛋白名称：
• Complement component C6

• Human Gene Id：
• 729

• Human Swiss Prot No：
• P13671

• Rat Gene Id：
• 24237

• Rat Swiss Prot No：
• Q811M5

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human C6. AA range:221-270

• 特异性：
• C6 Polyclonal Antibody detects endogenous levels of C6 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• C6;Complement component C6

• 分子量：
• 105kD

• 实测条带：
• 85-105kD

• 背景：
• This gene encodes a component of the complement cascade. The encoded protein is part of the membrane attack complex that can be incorporated into the cell membrane and cause cell lysis. Mutations in this gene are associated with complement component-6 deficiency. Transcript variants encoding the same protein have been described.[provided by RefSeq, Nov 2012],

• 功能：
• disease:Defects in C6 are the cause of complement component 6 deficiency (C6D) [MIM:612446].,function:Involved in the formation of the lytic c5b-9m complex.,online information:C6 mutation db,polymorphism:The sequence shown is that of allotype C6 B.,PTM:All cysteine residues are assumed to be cross-linked to one another. Individual modules containing an even number of conserved cysteine residues are supposed to have disulfide linkages only within the same module.,similarity:Belongs to the complement C6/C7/C8/C9 family.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 LDL-receptor class A domain.,similarity:Contains 1 MACPF domain.,similarity:Contains 2 Sushi (CCP/SCR) domains.,similarity:Contains 3 TSP type-1 domains.,

• 细胞定位：
• Secreted.

• 组织表达：
• Blood,Ovary,Plasma,

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