• 靶点：
• GABAA Rβ1

• 简介：
• >>Neuroactive ligand-receptor interaction;>>Retrograde endocannabinoid signaling;>>Serotonergic synapse;>>GABAergic synapse;>>Morphine addiction;>>Nicotine addiction

• 基因名称：
• GABRB1

• 蛋白名称：
• Gamma-aminobutyric acid receptor subunit beta-1

• Human Gene Id：
• 2560

• Human Swiss Prot No：
• P18505

• Mouse Gene Id：
• 14400

• Mouse Swiss Prot No：
• P50571

• Rat Gene Id：
• 25450

• Rat Swiss Prot No：
• P15431

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human GABA-RB around the phosphorylation site of Ser434. AA range:401-450

• 特异性：
• Phospho-GABAA Rβ1 (S434) Polyclonal Antibody detects endogenous levels of GABAA Rβ1 protein only when phosphorylated at S434.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• GABRB1;Gamma-aminobutyric acid receptor subunit beta-1;GABA(A) receptor subunit beta-1

• 实测条带：
• 55kD

• 背景：
• The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 1 subunit. It is mapped to chromosome 4p12 in a cluster comprised of genes encoding alpha 4, alpha 2 and gamma 1 subunits of the GABA A receptor. Alteration of this gene is implicated in the pathogenetics of schizophrenia. [provided by RefSeq, Jul 2008],

• 功能：
• function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.,online information:Forbidden fruit - Issue 56 of March 2005,similarity:Belongs to the ligand-gated ionic channel (TC 1.A.9) family.,subunit:Binds UBQLN1 (By similarity). Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.,

• 细胞定位：
• Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein .

• 组织表达：
• Brain,Epithelium,

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