• 靶点：
• Dynamin I

• 简介：
• >>Phospholipase D signaling pathway;>>Endocytosis;>>Synaptic vesicle cycle;>>Endocrine and other factor-regulated calcium reabsorption;>>Bacterial invasion of epithelial cells

• 基因名称：
• DNM1

• 蛋白名称：
• Dynamin-1

• Human Gene Id：
• 1759

• Human Swiss Prot No：
• Q05193

• Mouse Gene Id：
• 13429

• Mouse Swiss Prot No：
• P39053

• Rat Gene Id：
• 140694

• Rat Swiss Prot No：
• P21575

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human DYN1 around the phosphorylation site of Ser778. AA range:751-800

• 特异性：
• Phospho-Dynamin I (S778) Polyclonal Antibody detects endogenous levels of Dynamin I protein only when phosphorylated at S778.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• DNM1;DNM;Dynamin-1

• 实测条带：
• 100kD

• 背景：
• dynamin 1(DNM1) Homo sapiens This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008],

• 功能：
• catalytic activity:GTP + H(2)O = GDP + phosphate.,function:Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis.,similarity:Belongs to the dynamin family.,similarity:Contains 1 GED domain.,similarity:Contains 1 PH domain.,subcellular location:Microtubule-associated.,subunit:Interacts with CAV1 and SH3GLB1. Binds SH3GL1, SH3GL2 and SH3GL3.,

• 细胞定位：
• Cytoplasm . Cytoplasm, cytoskeleton . Microtubule-associated.

• 组织表达：
• Brain,Platelet,PNS,

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