EAAT2 Polyclonal Antibody

    • 货号：YN5616
    • 应用：WB
    • 种属：Human;Rat;Mouse
      • 靶点：
      • EAAT2
      • 简介：
      • >>Synaptic vesicle cycle;>>Glutamatergic synapse;>>Amyotrophic lateral sclerosis;>>Huntington disease
      • 基因名称：
      • SLC1A2
      • 蛋白名称：
      • Excitatory amino acid transporter 2 (Glutamate/aspartate transporter II) (Sodium-dependent glutamate/aspartate transporter 2) (Solute carrier family 1 member 2)
      • Human Gene Id：
      • 6506
      • Human Swiss Prot No：
      • P43004
      • Mouse Swiss Prot No：
      • P43006
      • 免疫原：
      • Synthetic Peptide of EAAT2 AA range: 370-420
      • 特异性：
      • EAAT2 protein(A223) detects endogenous levels of EAAT2
      • 组成：
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • 来源：
      • Polyclonal, Rabbit,IgG
      • 稀释：
      • WB 1:1000-2000
      • 纯化工艺：
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • 浓度：
      • 1 mg/ml
      • 储存：
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • 其他名称：
      • Excitatory amino acid transporter 2 (Glutamate/aspartate transporter II) (Sodium-dependent glutamate/aspartate transporter 2) (Solute carrier family 1 member 2)
      • 实测条带：
      • 62kD
      • 背景：
      • This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Sep 2010],
      • 功能：
      • function:Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.,PTM:Glycosylated.,similarity:Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family.,subunit:Homotrimer. Interacts with JUB.,
      • 细胞定位：
      • Cell membrane ; Multi-pass membrane protein .
      • 组织表达：
      • Brain,Brain cortex,Pancreas,
      • 产品图片
      • Western blot analysis of 1) Mouse Brain Tissue, 2)Rat Brain Tissue with EAAT2 Rabbit pAb diluted at 1:2,000.

      相关报价

      • 货号：
      • YN5616
      • 规格：
      • 40μL / 100μL / 200μL
      • 价格：
      • ¥960 / 2300 / 3780
      • 货期：
      • 预计发货时间为
        2024-05-08
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