L-type Ca++ CP γ5 Polyclonal Antibody
- 货号：YN5520
- 应用：WB;IHC;IF
- 种属：Human;Mouse;Rat
- 简介：
- >>MAPK signaling pathway;>>Cardiac muscle contraction;>>Adrenergic signaling in cardiomyocytes;>>Oxytocin signaling pathway;>>Hypertrophic cardiomyopathy;>>Arrhythmogenic right ventricular cardiomyopathy;>>Dilated cardiomyopathy
- 蛋白名称：
- Voltage-dependent calcium channel gamma-5 subunit
- 免疫原：
- Synthetic Peptide of L-type Ca++ CP γ5 AA range: 110-190
- 特异性：
- The antibody detects endogenous L-type Ca++ CP γ5 protein.
- 组成：
- PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- WB 1:500-1000 IHC 1:100-200. IF 1:50-200
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- CACNG5;Voltage-dependent calcium channel gamma-5 subunit;Neuronal voltage-gated calcium channel gamma-5 subunit;Transmembrane AMPAR regulatory protein gamma-5;TARP gamma-5
- 背景：
- calcium voltage-gated channel auxiliary subunit gamma 5(CACNG5) Homo sapiens The protein encoded by this gene is a type II transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type I TARP and a calcium channel gamma subunit. This gene is a susceptibility locus for schizophrenia and bipolar disorder. [provided by RefSeq, Dec 2010],
- 功能：
- function:Thought to stabilize the calcium channel in an inactivated (closed) state.,similarity:Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.,subunit:The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma.,
- 细胞定位：
- Membrane ; Multi-pass membrane protein . Cell junction, synapse, postsynaptic density membrane .
- 组织表达：
- Brain cortex,Thalamus,
- Western blot analysis of 1) Human Brain Tissue, 2) Mouse Brain Tissue, 3) Rat Brain Tissue using L-type Ca++ CP γ5 Polyclonal Antibody. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
- Immunohistochemical analysis of paraffin-embedded Rat Brain Tissue using L-type Ca++ CP γ5 Polyclonal Antibody.
