PRLR Polyclonal Antibody

  • 货号：YN2369
  • 应用：WB;ELISA
  • 种属：Human
    • 靶点：
    • PRLR
    • 简介：
    • >>Cytokine-cytokine receptor interaction;>>Neuroactive ligand-receptor interaction;>>PI3K-Akt signaling pathway;>>JAK-STAT signaling pathway;>>Prolactin signaling pathway
    • 基因名称：
    • PRLR
    • 蛋白名称：
    • Prolactin receptor (PRL-R)
    • Human Gene Id：
    • 5618
    • Human Swiss Prot No：
    • P16471
    • Mouse Swiss Prot No：
    • Q08501
    • 免疫原：
    • Synthesized peptide derived from human protein . at AA range: 80-160
    • 特异性：
    • PRLR Polyclonal Antibody detects endogenous levels of protein.
    • 组成：
    • Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
    • 来源：
    • Polyclonal, Rabbit,IgG
    • 稀释：
    • WB 1:500-2000 ELISA 1:5000-20000
    • 纯化工艺：
    • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • 浓度：
    • 1 mg/ml
    • 储存：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • 实测条带：
    • 68kD
    • 背景：
    • This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer. [provided by RefSeq, Feb 2011],
    • 功能：
    • domain:The box 1 motif is required for JAK interaction and/or activation.,domain:The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.,function:This is a receptor for the anterior pituitary hormone prolactin (PRL). Isoforms 4 and 6 are unable to transduce prolactin signaling.,similarity:Belongs to the type I cytokine receptor family. Type 1 subfamily.,similarity:Contains 2 fibronectin type-III domains.,subcellular location:Isoform 7.,subunit:Interacts with SMARCA1. Interacts with GH1.,tissue specificity:Expressed in breast, placenta, kidney, liver and pancreas.,
    • 细胞定位：
    • Membrane ; Single-pass type I membrane protein .; [Isoform 7]: Secreted.
    • 组织表达：
    • Expressed in breast, placenta, kidney, liver and pancreas.

    相关报价

    • 货号：
    • YN2369
    • 规格：
    • 40μL / 100μL / 200μL
    • 价格：
    • 960 / 2300 / 3780
    • 货期：
    • 预计发货时间为
      2024-04-28
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