FGF3 Polyclonal Antibody

    • 货号:YN2306
    • 应用:WB;ELISA
    • 种属:Human;Mouse
      • 靶点:
      • FGF3
      • 简介:
      • >>MAPK signaling pathway;>>Ras signaling pathway;>>Rap1 signaling pathway;>>Calcium signaling pathway;>>PI3K-Akt signaling pathway;>>Regulation of actin cytoskeleton;>>Pathways in cancer;>>Chemical carcinogenesis - receptor activation;>>Melanoma;>>Breast cancer;>>Gastric cancer
      • 基因名称:
      • FGF3 INT2
      • 蛋白名称:
      • Fibroblast growth factor 3 (FGF-3) (Heparin-binding growth factor 3) (HBGF-3) (Proto-oncogene Int-2)
      • Human Gene Id:
      • 2248
      • Human Swiss Prot No:
      • P11487
      • Mouse Swiss Prot No:
      • P05524
      • 免疫原:
      • Synthesized peptide derived from human protein . at AA range: 130-210
      • 特异性:
      • FGF3 Polyclonal Antibody detects endogenous levels of protein.
      • 组成:
      • Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
      • 来源:
      • Polyclonal, Rabbit,IgG
      • 稀释:
      • WB 1:500-2000 ELISA 1:5000-20000
      • 纯化工艺:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • 浓度:
      • 1 mg/ml
      • 储存:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • 实测条带:
      • 26kD
      • 背景:
      • The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary tumors in the mouse. Frequent amplification of this gene has been found in human tumors, which may be important for neoplastic transformation and tumor progression. Studies of the similar genes in mouse and chicken suggested the role in inner ear formation. [provided by RefSeq, Jul 2008],
      • 功能:
      • disease:Defects in FGF3 are a cause of congenital deafness with inner ear agenesis microtia and microdontia [MIM:610706]. This disorder consits of a unique autosomal recessive syndrome characterized by type I microtia, microdontia, and profound congenital deafness associated with a complete absence of inner ear structures (Michel aplasia).,function:Could be involved in ear development.,similarity:Belongs to the heparin-binding growth factors family.,
      • 细胞定位:
      • Secreted .
      • 组织表达:
      • Placenta,
      • 产品图片
      • Western blot analysis of lysates from HCT116 cells, primary antibody was diluted at 1:1000, 4°over night