• 靶点：
• ORC5

• 简介：
• >>Cell cycle

• 基因名称：
• ORC5 ORC5L

• 蛋白名称：
• Origin recognition complex subunit 5

• Human Gene Id：
• 5001

• Human Swiss Prot No：
• O43913

• Mouse Swiss Prot No：
• Q9WUV0

• 免疫原：
• Synthesized peptide derived from part region of human protein

• 特异性：
• ORC5 Polyclonal Antibody detects endogenous levels of protein.

• 组成：
• Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000 ELISA 1:5000-20000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 实测条带：
• 47kD

• 背景：
• The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Oct 2010],

• 功能：
• function:Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. Binds to the ARS consensus sequence (ACS) of origins of replication in an ATP-dependent manner.,similarity:Belongs to the ORC5 family.,subunit:ORC is composed of six subunits.,

• 细胞定位：
• Nucleus . Chromosome .

• 组织表达：
• Abundant in spleen, ovary, prostate, testis, and colon mucosa.

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