LTOR3 Polyclonal Antibody
- 货号：YN1616
- 应用：WB;ELISA
- 种属：Human;Mouse;Rat
- 简介：
- >>MAPK signaling pathway;>>mTOR signaling pathway
- 基因名称：
- LAMTOR3 MAP2K1IP1 MAPKSP1 PRO2783
- 蛋白名称：
- Ragulator complex protein LAMTOR3 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3) (MEK-binding partner 1) (Mp1) (Mitogen-activated protein kinase kinase 1-interacting protein 1) (Mito
- 免疫原：
- Synthesized peptide derived from human protein . at AA range: 30-110
- 特异性：
- LTOR3 Polyclonal Antibody detects endogenous levels of protein.
- 组成：
- Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- WB 1:500-2000 ELISA 1:5000-20000
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 背景：
- This gene encodes a scaffold protein that functions in the extracellular signal-regulated kinase (ERK) cascade. The protein is localized to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. Studies of the orthologous gene in mouse indicate that it regulates late endosomal traffic and cell proliferation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 13. [provided by RefSeq, Aug 2011],
- 功能：
- function:Adapter protein that enhances the efficiency of the MAP kinase cascade. Facilitates the activation of MAPK2.,similarity:Belongs to the MAPKSP1 family.,subunit:Interacts with MAP2K1 and MAPK2. Interacts with MORG1 (By similarity). Heterodimer with MAPBPIP.,
- 细胞定位：
- Late endosome membrane ; Peripheral membrane protein ; Cytoplasmic side .
- 组织表达：
- Brain,Dendritic cell,Fetal liver,Liver,Lung
- Western blot analysis of lysates from Jurkat cells, primary antibody was diluted at 1:1000, 4°over night
