• 靶点：
• GRP3

• 简介：
• >>MAPK signaling pathway;>>Ras signaling pathway;>>Rap1 signaling pathway;>>B cell receptor signaling pathway;>>Pathways in cancer

• 基因名称：
• RASGRP3 GRP3 KIAA0846

• 蛋白名称：
• Ras guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1)

• Human Gene Id：
• 25780

• Human Swiss Prot No：
• Q8IV61

• 免疫原：
• Synthesized peptide derived from human protein . at AA range: 90-170

• 特异性：
• GRP3 Polyclonal Antibody detects endogenous levels of protein.

• 组成：
• Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000 ELISA 1:5000-20000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 实测条带：
• 75kD

• 背景：
• RAS guanyl releasing protein 3(RASGRP3) Homo sapiens Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008],

• 功能：
• function:Guanine nucleotide exchange factor (GEF) for Ras and Rap1.,similarity:Belongs to the RASGRP family.,similarity:Contains 1 N-terminal Ras-GEF domain.,similarity:Contains 1 phorbol-ester/DAG-type zinc finger.,similarity:Contains 1 Ras-GEF domain.,similarity:Contains 2 EF-hand domains.,

• 细胞定位：
• intracellular,plasma membrane,integral component of plasma membrane,guanyl-nucleotide exchange factor complex,perinuclear region of cytoplasm,

• 组织表达：
• Brain,

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