• 靶点：
• Parathyroid Hormone

• 简介：
• >>Neuroactive ligand-receptor interaction;>>Parathyroid hormone synthesis, secretion and action;>>Endocrine and other factor-regulated calcium reabsorption;>>Rheumatoid arthritis

• 基因名称：
• PTH

• 蛋白名称：
• Parathyroid hormone (PTH) (Parathormone) (Parathyrin)

• Human Gene Id：
• 5741

• Human Swiss Prot No：
• P01270

• 免疫原：
• Synthesized peptide derived from human Parathyroid Hormone (PTH) AA range: 50-115

• 特异性：
• This antibody detects endogenous levels of human Parathyroid Hormone (PTH). Heat-induced epitope retrieval (HIER) TRIS-EDTA of pH8.0 was highly recommended as antigen repair method in paraffin section

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Mouse, Monoclonal/IgG1, Kappa

• 稀释：
• IHC 1:200-400, ELISA 1:5000-20000

• 纯化工艺：
• The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 背景：
• This gene encodes a member of the parathyroid family of proteins. The encoded preproprotein is proteolytically processed to generate a protein that binds to the parathyroid hormone/parathyroid hormone-related peptide receptor and regulates blood calcium and phosphate levels. Excess production of the encoded protein, known as hyperparathyroidism, can result in hypercalcemia and kidney stones. On the other hand, defective processing of the encoded protein may lead to hypoparathyroidism, which can result in hypocalcemia and numbness. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015],

• 功能：
• disease:Defects in PTH are a cause of familial isolated hypoparathyroidism (FIH) [MIM:146200]. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.,function:PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion.,online information:Parathyroid hormone entry,similarity:Belongs to the parathyroid hormone family.,

• 细胞定位：
• Cytoplasmic, Membranous

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