• 靶点：
• MyoD

• 简介：
• >>Spinocerebellar ataxia

• 基因名称：
• MYOD1 BHLHC1 MYF3 MYOD

• 蛋白名称：
• Myoblast determination protein 1 (Class C basic helix-loop-helix protein 1) (bHLHc1) (Myogenic factor 3) (Myf-3)

• Human Gene Id：
• 4654

• Human Swiss Prot No：
• P15172

• 免疫原：
• Synthesized peptide derived from human MyoD1 AA range: 100-200

• 特异性：
• This antibody detects endogenous levels of human MyoD1. Heat-induced epitope retrieval (HIER) Citrate buffer of pH6.0 was highly recommended as antigen repair method in paraffin section

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Mouse, Monoclonal/IgG2b, Kappa

• 稀释：
• IHC 1:200-400,WB 1:100-2000, ELISA 1:5000-20000

• 纯化工艺：
• The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 35kD

• 背景：
• This gene encodes a nuclear protein that belongs to the basic helix-loop-helix family of transcription factors and the myogenic factors subfamily. It regulates muscle cell differentiation by inducing cell cycle arrest, a prerequisite for myogenic initiation. The protein is also involved in muscle regeneration. It activates its own transcription which may stabilize commitment to myogenesis. [provided by RefSeq, Jul 2008],

• 功能：
• function:Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Activates muscle-specific promoters. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins.,online information:MyoD entry,PTM:Acetylated by a complex containing EP300 and PCAF. The acetylation is essential to activate target genes. Conversely, its deacetylation by SIRT1 inhibits its function.,PTM:Ubiquitinated on the N-terminus; which is required for proteasomal degradation.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subunit:Efficient DNA binding requires dimerization with another bHLH protein. Seems to form active heterodimers with ITF-2. Interacts with SUV39H1.,

• 细胞定位：
• Nucleus.

• 组织表达：
• Muscle,Skeletal muscle,

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