PRMT1 Monoclonal Antibody
- 货号：YM1084
- 应用：WB
- 种属：Human;Mouse;Rat;Dog;Rabbit
- 简介：
- >>FoxO signaling pathway;>>Glucagon signaling pathway
- 蛋白名称：
- Protein arginine N-methyltransferase 1
- 免疫原：
- Purified recombinant human PRMT1 protein fragments expressed in E.coli.
- 特异性：
- PRMT1 Monoclonal Antibody detects endogenous levels of PRMT1 protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 稀释：
- WB 1:1000 - 1:2000. Not yet tested in other applications.
- 纯化工艺：
- Affinity purification
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- PRMT1;HMT2;HRMT1L2;IR1B4;Protein arginine N-methyltransferase 1;Histone-arginine N-methyltransferase PRMT1;Interferon receptor 1-bound protein 4
- 背景：
- This gene encodes a member of the protein arginine N-methyltransferase (PRMT) family. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to terminal guanidino nitrogen atoms. The encoded protein is a type I PRMT and is responsible for the majority of cellular arginine methylation activity. Increased expression of this gene may play a role in many types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011],
- 功能：
- enzyme regulation:By BTG1, BTG2 and ILF3.,function:Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in a glycine and arginine-rich domain (may methylate HNRNPA1 and histones). Methylates SUPT5H and EWS.,similarity:Belongs to the protein arginine N-methyltransferase family.,subunit:Homodimer and heterodimer with PRMT8. The dimer can then associate to form a homohexamer. Interacts with ILF3, BTG1, BTG2, SUPT5H and interferon-alpha/beta receptor 1. Interacts with NFATC2IP.,
- 细胞定位：
- Nucleus . Nucleus, nucleoplasm . Cytoplasm . Cytoplasm, cytosol . Mostly found in the cytoplasm. Colocalizes with CHTOP within the nucleus. Low levels detected also in the chromatin fraction (By similarity). .
- 组织表达：
- Widely expressed (PubMed:11097842). Expressed strongly in colorectal cancer cells (at protein level) (PubMed:28040436). Expressed strongly in colorectal cancer tissues compared to wild-type colon samples (at protein level) (PubMed:28040436). Expressed strongly in colorectal cancer tissues compared to wild-type colon samples (PubMed:28040436).
- Western Blot analysis using PRMT1 Monoclonal Antibody against HeLa, A549 cell lysate.
