IL-34 Monoclonal Antibody

    • 货号:YM0371
    • 应用:WB;IF;FCM;ELISA
    • 种属:Human
      • 靶点:
      • IL-34
      • 简介:
      • >>Cytokine-cytokine receptor interaction;>>Viral protein interaction with cytokine and cytokine receptor
      • 基因名称:
      • IL34
      • 蛋白名称:
      • Interleukin-34
      • Human Swiss Prot No:
      • Q6ZMJ4
      • Mouse Swiss Prot No:
      • Q8R1R4
      • 免疫原:
      • Purified recombinant fragment of human IL-34 expressed in E. Coli.
      • 特异性:
      • IL-34 Monoclonal Antibody detects endogenous levels of IL-34 protein.
      • 组成:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • 来源:
      • Monoclonal, Mouse
      • 稀释:
      • WB 1:500 - 1:2000. IF 1:200 - 1:1000. Flow cytometry: 1:200 - 1:400. ELISA: 1:10000. Not yet tested in other applications.
      • 纯化工艺:
      • Affinity purification
      • 储存:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • 其他名称:
      • IL34;C16orf77;Interleukin-34;IL-34
      • 分子量:
      • 27kD
      • 背景:
      • Interleukin-34 is a cytokine that promotes the differentiation and viability of monocytes and macrophages through the colony-stimulating factor-1 receptor (CSF1R; MIM 164770) (Lin et al., 2008 [PubMed 18467591]).[supplied by OMIM, May 2008],
      • 功能:
      • function:Cytokine that promotes the differentiation and viability of monocytes and macrophages. Stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1. Ligand for colony-stimulating factor-1 receptor CSF1R.,similarity:Belongs to the IL-34 family.,subunit:Homodimer.,tissue specificity:Detected in the sinusoidal epithelium in the red pulp of spleen (at protein level). Predominantly expressed in spleen. Also detected in a range of other tissues including heart, brain, lung, liver, kidney, thymus, testis, ovary, small intestine, prostate and colon.,
      • 细胞定位:
      • Secreted .
      • 组织表达:
      • Detected in the sinusoidal epithelium in the red pulp of spleen (at protein level). Predominantly expressed in spleen. Also detected in a range of other tissues including heart, brain, lung, liver, kidney, thymus, testis, ovary, small intestine, prostate and colon.
      • 产品图片
      • Western Blot analysis using IL-34 Monoclonal Antibody against IL-34-hIgGFc transfected HEK293 cell lysate.
      • Immunofluorescence analysis of U251 cells using IL-34 Monoclonal Antibody (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
      • Flow cytometric analysis of K562 cells using IL-34 Monoclonal Antibody (green) and negative control (purple).