• 靶点：
• IKKε

• 简介：
• >>Toll-like receptor signaling pathway;>>NOD-like receptor signaling pathway;>>RIG-I-like receptor signaling pathway;>>Cytosolic DNA-sensing pathway;>>C-type lectin receptor signaling pathway;>>IL-17 signaling pathway;>>Alcoholic liver disease;>>Hepatitis C;>>Hepatitis B;>>Measles;>>Influenza A;>>Human papillomavirus infection;>>Kaposi sarcoma-associated herpesvirus infection;>>Herpes simplex virus 1 infection;>>Epstein-Barr virus infection;>>Coronavirus disease - COVID-19;>>Chemical carcinogenesis - receptor activation;>>Lipid and atherosclerosis

• 基因名称：
• IKBKE

• 蛋白名称：
• Inhibitor of nuclear factor kappa-B kinase subunit epsilon

• Human Gene Id：
• 9641

• Human Swiss Prot No：
• Q14164

• Mouse Swiss Prot No：
• Q9R0T8

• 免疫原：
• Purified recombinant fragment of IKKε (aa1-257) expressed in E. Coli.

• 特异性：
• IKKε Monoclonal Antibody detects endogenous levels of IKKε protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Monoclonal, Mouse

• 稀释：
• WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

• 纯化工艺：
• Affinity purification

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• IKBKE;IKKE;IKKI;KIAA0151;Inhibitor of nuclear factor kappa-B kinase subunit epsilon;I-kappa-B kinase epsilon;IKK-E;IKK-epsilon;IkBKE;Inducible I kappa-B kinase;IKK-i

• 分子量：
• 80kD

• 背景：
• IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009 [PubMed 19481526]).[supplied by OMIM, Oct 2009],

• 功能：
• catalytic activity:ATP + [I-kappa-B protein] = ADP + [I-kappa-B phosphoprotein].,function:Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. May play a special role in the immune response.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.,similarity:Contains 1 protein kinase domain.,subunit:May interact with MAVS/IPS1. Interacts with AZI2. Interacts with SIKE. Interacts with TICAM1/TRIF, IRF3 and DDX58/RIG-I, interactions are disrupted by the interaction between IKBKE and SIKE.,tissue specificity:Highly expressed in spleen followed by thymus, peripheral blood leukocytes, pancreas, placenta. Weakly expressed in lung, kidney, prostate, ovary and colon.,

• 细胞定位：
• Cytoplasm . Nucleus. Nucleus, PML body . Targeting to PML nuclear bodies upon DNA damage is TOPORS-dependent (PubMed:20188669). Located diffusely throughout the cytoplasm but locates to punctate cytoplasmic bodies when coexpressed with TRIM6 (PubMed:24882218). .

• 组织表达：
• Highly expressed in spleen followed by thymus, peripheral blood leukocytes, pancreas, placenta. Weakly expressed in lung, kidney, prostate, ovary and colon.

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