• 靶点：
• MSH6

• 简介：
• >>Platinum drug resistance;>>Mismatch repair;>>Pathways in cancer;>>Colorectal cancer

• 基因名称：
• MSH6

• 蛋白名称：
• DNA mismatch repair protein Msh6

• Human Gene Id：
• 2956

• Human Swiss Prot No：
• P52701

• Mouse Swiss Prot No：
• P54276

• 免疫原：
• Purified recombinant fragment of human GTBP expressed in E. Coli.

• 特异性：
• GTBP Monoclonal Antibody detects endogenous levels of GTBP protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Monoclonal, Mouse

• 稀释：
• WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

• 纯化工艺：
• Affinity purification

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• MSH6;GTBP;DNA mismatch repair protein Msh6;hMSH6;G/T mismatch-binding protein;GTBP;GTMBP;MutS-alpha 160 kDa subunit;p160

• 分子量：
• 153kD

• 背景：
• This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described. [provided by RefSeq, Jul 2013],

• 功能：
• disease:Defects in MSH6 are a cause of susceptibility to endometrial cancer [MIM:608089].,disease:Defects in MSH6 are the cause of hereditary non-polyposis colorectal cancer type 5 (HNPCC5) [MIM:600678]. Mutations in more than one gene locus can be involved alone or in combination in the production of the HNPCC phenotype (also called Lynch syndrome). Most families with clinically recognized HNPCC have mutations in either MLH1 or MSH2 genes. HNPCC is an autosomal, dominantly inherited disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early onset colorectal carcinoma (CRC) and extra-colonic cancers of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited colorectal cancer in the Western world. Cancers in HNPCC originate within benign neoplastic polyps ter

• 细胞定位：
• Nucleus . Chromosome . Associates with H3K36me3 via its PWWP domain.

• 组织表达：
• Epithelium,Placenta,Pooled,Testis,

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