Cerberus Monoclonal Antibody
- 货号：YM0149
- 应用：WB;IHC;IF;ELISA
- 种属：Human
- 简介：
- >>Wnt signaling pathway
- 免疫原：
- Purified recombinant fragment of human Cerberus expressed in E. Coli.
- 特异性：
- Cerberus Monoclonal Antibody detects endogenous levels of Cerberus protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 稀释：
- WB 1:500 - 1:2000. IHC 1:200 - 1:1000. ELISA: 1:10000.. IF 1:50-200
- 纯化工艺：
- Affinity purification
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- CER1;DAND4;Cerberus;Cerberus-related protein;DAN domain family member 4
- 背景：
- This gene encodes a cytokine member of the cysteine knot superfamily, characterized by nine conserved cysteines and a cysteine knot region. The cerberus-related cytokines, together with Dan and DRM/Gremlin, represent a group of bone morphogenetic protein (BMP) antagonists that can bind directly to BMPs and inhibit their activity. [provided by RefSeq, Jul 2008],
- 功能：
- function:Cytokine that may play a role in anterior neural induction and somite formation during embryogenesis in part through a BMP-inhibitory mechanism. Can regulate Nodal signaling during gastrulation as well as the formation and patterning of the primitive streak.,PTM:N-glycosylated.,sequence caution:Translated as Ser.,similarity:Belongs to the DAN family.,similarity:Contains 1 CTCK (C-terminal cystine knot-like) domain.,subunit:Forms monomers and predominantly dimers.,
- 组织表达：
- Blood,PCR rescued clones,
- Western Blot analysis using Cerberus Monoclonal Antibody against CER1 (aa18-267)-hIgGFc transfected HEK293 cell lysate (1).
- Immunohistochemistry analysis of paraffin-embedded human gastric cancer (left) and normal gastric tissues (right) with DAB staining using Cerberus Monoclonal Antibody.
