Synthesized peptide derived from human RBP AA range: 11-60

This antibody detects endogenous levels of Human RBP

RBP4 PRO2222

Retinol-binding protein 4

Retinol-binding protein 4 ;
Plasma retinol-binding protein ;
PRBP ;
RBP ;
[Cleaved into: Plasma retinol-binding protein ;
1-182 ;
Plasma retinol-binding protein ;
1-181 ;
Plasma retinol-binding protein ;
1-179 ;
Plasma retinol-binding protein ;
1-176 ;
]

retinol binding protein 4(RBP4) Homo sapiens This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells. [provided by RefSeq, Jul 2008],

Disease:A deficiency of vitamin A blocks secretion of the binding protein post-translationally and results in defective delivery and supply of vitamin to the epidermal cells (a condition associated with a dermatosis).,Disease:Defects in RBP4 are a cause of retinol-binding protein deficiency [MIM:180250]. This condition causes night vision problems. It produces a typical "fundus xerophthalmicus," featuring a progressed atrophy of the retinal pigment epithelium.,Function:Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.,mass spectrometry: PubMed:12237133,mass spectrometry: PubMed:7666002,online information:Retina International's Scientific Newsletter,online information:Retinol-binding protein 4 entry,similarity:Belongs to the calycin superfamily. Lipocalin family.,

Secreted .

Detected in blood plasma and in urine (at protein level).