Catalog: YT7460
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
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Main Information
Target
PP12C
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
WB, IHC
MW
86kD (Calculated)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000; IHC 1:50-300
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
This antibody detects endogenous levels of PP12C at Human/Mouse
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Calculated)
86kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from human PP12C AA range: 542-592
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Specificity:
This antibody detects endogenous levels of PP12C at Human/Mouse
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Gene Name:
PPP1R12C LENG3 MBS85
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Protein Name:
PP12C
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Background:
The gene encodes a subunit of myosin phosphatase. The encoded protein regulates the catalytic activity of protein phosphatase 1 delta and assembly of the actin cytoskeleton. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012],
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Function:
Caution:Although assigned as two separate genes (PPP1R12C and LENG3), it is probable that LENG3 does not exist by itself and is a part of the PPP1R12C gene.,Function:Regulates myosin phosphatase activity.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence Caution:Unspliced mRNA.,similarity:Contains 4 ANK repeats.,subcellular location:Along actomyosin filaments and stress fibers.,subunit:PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, and one or several targeting or regulatory subunits. PPP1R12C mediates binding to myosin. Interacts via its N-terminus with PPP1CB. Interacts with IL16. Interacts with the coiled-coil domain of MPRIP.,tissue specificity:Ubiquitously expressed. Highly expressed in heart.,
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Cellular Localization:
Cytoplasm . Cytoplasm, cytoskeleton, stress fiber .
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Tissue Expression:
Ubiquitously expressed. Highly expressed in heart.
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Research Areas:
>>Vascular smooth muscle contraction ;
>>Focal adhesion ;
>>Regulation of actin cytoskeleton ;
>>Oxytocin signaling pathway ;
>>Proteoglycans in cancer
>>Focal adhesion ;
>>Regulation of actin cytoskeleton ;
>>Oxytocin signaling pathway ;
>>Proteoglycans in cancer
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YT7460
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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