Synthesized peptide derived from human TGM5 AA range: 448-498

This antibody detects endogenous levels of TGM5 at Human/Mouse

TGM5 TGMX

TGM5

This gene encodes a member of the transglutaminase family. The encoded protein catalyzes formation of protein cross-links between glutamine and lysine residues, often resulting in stabilization of protein assemblies. This reaction is calcium dependent. Mutations in this gene have been associated with acral peeling skin syndrome. [provided by RefSeq, Oct 2009],

Catalytic activity:Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH(3).,Caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,cofactor:Binds 1 calcium ion per subunit.,Disease:Defects in TGM5 are a cause of peeling skin syndrome acral type (APSS) [MIM:609796, 270300]. Peeling skin syndrome (PSS) is an autosomal recessive genodermatosis characterized by the continuous shedding of the outer layers of the epidermis from birth and throughout life. In some cases of PSS, skin peeling is accompanied by erythema, vesicular lesions, or, in rare cases, other ectodermal features, like fragile hair and nail abnormalities. Two main subtypes, noninflammatory type A and inflammatory type B, have been suggested. However, it is clear from the dermatology literature that there are additional subtypes. In some families, an acral form of PSS (APSS) has been reported, in which skin peeling is strictly limited to the dorsa of the hands and feet, and, again, ultrastructural and histological analysis shows a level of blistering high in the epidermis at the stratum granulosum-stratum corneum junction.,Function:Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Contributes to the formation of the cornified cell envelope of keratinocytes.,induction:By tetradecanoylphorbolacetate (TPA) and calcium in NHEK cells.,similarity:Belongs to the transglutaminase superfamily. Transglutaminase family.,subcellular location:Associated with intermediate filaments.,tissue specificity:Expressed in foreskin keratinocytes.,

Cytoplasm . Associated with intermediate filaments.

Expressed in foreskin keratinocytes.