Catalog: YT6811
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
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Main Information
Target
CMPK2
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
WB
MW
49kD (Calculated)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
This antibody detects endogenous levels of CMPK2 at Human/Mouse
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Calculated)
49kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from human CMPK2 AA range: 57-107
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Specificity:
This antibody detects endogenous levels of CMPK2 at Human/Mouse
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Gene Name:
CMPK2
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Protein Name:
CMPK2
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Background:
This gene encodes one of the enzymes in the nucleotide synthesis salvage pathway that may participate in terminal differentiation of monocytic cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012],
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Function:
Catalytic activity:ATP + (d)CMP = ADP + (d)CDP.,Function:May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs.,similarity:Belongs to the thymidylate kinase family.,tissue specificity:Among all investigated tumors, leukemia cells show the most abundant expression.,
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Cellular Localization:
Mitochondrion .
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Tissue Expression:
Among all investigated tumors, leukemia cells show the most abundant expression.
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Research Areas:
>>Pyrimidine metabolism ;
>>Metabolic pathways ;
>>Nucleotide metabolism ;
>>Biosynthesis of cofactors
>>Metabolic pathways ;
>>Nucleotide metabolism ;
>>Biosynthesis of cofactors
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Reference Citation({{totalcount}})
Catalog: YT6811
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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