Catalog: YT6475
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
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Main Information
Target
ATS6
Host Species
Rabbit
Reactivity
Human
Applications
WB
MW
123kD (Calculated)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
This antibody detects endogenous levels of ATS6 at Human
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Calculated)
123kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from human ATS6 AA range: 989-1039
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Specificity:
This antibody detects endogenous levels of ATS6 at Human
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Gene Name:
ADAMTS6
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Protein Name:
ATS6
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Background:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. Expression of this gene may be regulated by the cytokine TNF-alpha. [provided by RefSeq, Mar 2016],
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Function:
cofactor:Binds 1 zinc ion per subunit.,Domain:The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.,induction:Isoform 1 and 2 expressions are up-regulated by TNF-alpha in retinal pigment epithelial cells.,PTM:The precursor is cleaved by a furin endopeptidase.,similarity:Contains 1 disintegrin domain.,similarity:Contains 1 peptidase M12B domain.,similarity:Contains 1 PLAC domain.,similarity:Contains 5 TSP type-1 domains.,tissue specificity:Expressed at low levels in placenta and barely detectable in a number of other tissues.,
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Cellular Localization:
Secreted, extracellular space, extracellular matrix .
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Tissue Expression:
Reference Citation({{totalcount}})
Catalog: YT6475
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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