This gene encodes a member of the basic leucine zipper protein family. The encoded protein functions as a transcriptional repressor when heterodimerizing with JUN. The protein may play a role in repression of interleukin-2 and matrix metalloproteinase-1 transcription.[provided by RefSeq, Feb 2009],
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Function:
Function:Functions as a negative regulator of AP-1-mediated transcription by heterodimerizing with JUN and binding DNA at 12-O-tetradecanoylphorbol-13-acetate response elements (TRE) (consensus: 5'-TGA[CG]TCA-3'). Represses IL2 and MMP1 promoter activities.,similarity:Belongs to the bZIP family.,similarity:Contains 1 bZIP domain.,subunit:Interacts with JUN.,
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Cellular Localization:
Nucleus .
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Tissue Expression:
Lung,
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Research Areas:
>>PD-L1 expression and PD-1 checkpoint pathway in cancer