Catalog: YT5687
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
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Collected
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Main Information
Target
CD269/BCMA
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
WB, ELISA
MW
20kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
CD269 Polyclonal Antibody detects endogenous levels of CD269 protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
20kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from the Internal region of human CD269.
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Specificity:
CD269 Polyclonal Antibody detects endogenous levels of CD269 protein.
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Gene Name:
TNFRSF17 BCM BCMA
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Protein Name:
Tumor necrosis factor receptor superfamily member 17
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Other Name:
TNFRSF17 ;
BCM ;
BCMA ;
Tumor necrosis factor receptor superfamily member 17 ;
B-cell maturation protein ;
CD269
BCM ;
BCMA ;
Tumor necrosis factor receptor superfamily member 17 ;
B-cell maturation protein ;
CD269
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Background:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq, Jul 2008],
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Function:
Disease:A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2.,Function:Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.,similarity:Contains 1 TNFR-Cys repeat.,subcellular location:Perinuclear Golgi-like structures.,subunit:Associates with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6.,tissue specificity:Expressed in mature B-cells, but not in T-cells or monocytes.,
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Cellular Localization:
Cell membrane; Single-pass type III membrane protein. Endomembrane system; Single-pass type III membrane protein. Perinuclear Golgi-like structures.
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Tissue Expression:
Expressed in mature B-cells, but not in T-cells or monocytes.
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Research Areas:
>>Cytokine-cytokine receptor interaction ;
>>Intestinal immune network for IgA production
>>Intestinal immune network for IgA production
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YT5687
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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