Catalog: YT5666
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
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Main Information
Target
Topo IIIα
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
WB, ELISA
MW
115kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
Topo IIIα Polyclonal Antibody detects endogenous levels of Topo IIIα protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
115kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from Topo IIIα . at AA range: 350-430
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Specificity:
Topo IIIα Polyclonal Antibody detects endogenous levels of Topo IIIα protein.
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Gene Name:
TOP3A
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Protein Name:
DNA topoisomerase 3-alpha
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Other Name:
TOP3A ;
TOP3 ;
DNA topoisomerase 3-alpha ;
DNA topoisomerase III alpha
TOP3 ;
DNA topoisomerase 3-alpha ;
DNA topoisomerase III alpha
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Background:
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus reducing the number of supercoils and altering the topology of DNA. This enzyme forms a complex with BLM which functions in the regulation of recombination in somatic cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016],
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Function:
Catalytic activity:ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.,Function:Reduces the number of supercoils in a highly negatively supercoiled DNA. Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells.,similarity:Belongs to the prokaryotic type I/III topoisomerase family.,subunit:Directly interacts with BLM and RMI1. Component of the RMI complex, containing at least TOP3A, RMI1 and RMI2. The RMI complex interacts with BLM.,tissue specificity:High expression is found in testis, heart, skeletal muscle and pancreas.,
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Cellular Localization:
Mitochondrion matrix .
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Tissue Expression:
High expression is found in testis, heart, skeletal muscle and pancreas.
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Research Areas:
>>Homologous recombination ;
>>Fanconi anemia pathway
>>Fanconi anemia pathway
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Reference Citation({{totalcount}})
Catalog: YT5666
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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