The antiserum was produced against synthesized peptide derived from the Internal region of human ITGAL. AA range:171-220

Integrin αL Polyclonal Antibody detects endogenous levels of Integrin αL protein.

ITGAL

Integrin alpha-L

ITGAL ;
CD11A ;
Integrin alpha-L ;
CD11 antigen-like family member A ;
Leukocyte adhesion glycoprotein LFA-1 alpha chain ;
LFA-1A ;
Leukocyte function-associated molecule 1 alpha chain ;
CD11a

integrin subunit alpha L(ITGAL) Homo sapiens ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

Domain:The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.,Function:Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.,similarity:Belongs to the integrin alpha chain family.,similarity:Contains 1 VWFA domain.,similarity:Contains 7 FG-GAP repeats.,subunit:Heterodimer of an alpha and a beta subunit. Alpha-L associates with beta-2.,tissue specificity:Leukocytes.,

Cell membrane ; Single-pass type I membrane protein .

Leukocytes.

>>Rap1 signaling pathway ;
>>Cell adhesion molecules ;
>>Neutrophil extracellular trap formation ;
>>Natural killer cell mediated cytotoxicity ;
>>Leukocyte transendothelial migration ;
>>Regulation of actin cytoskeleton ;
>>Malaria ;
>>Staphylococcus aureus infection ;
>>Human T-cell leukemia virus 1 infection ;
>>Epstein-Barr virus infection ;
>>Rheumatoid arthritis ;
>>Viral myocarditis