Catalog: YT5303
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
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Main Information
Target
BMP-3
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, IF, ELISA
MW
53kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; IHC: 1:100-1:300; ELISA 1:20000; IF 1:50-200
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
BMP-3A Polyclonal Antibody detects endogenous levels of BMP-3A protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
53kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from the C-terminal region of human BMP3. AA range:421-470
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Specificity:
BMP-3A Polyclonal Antibody detects endogenous levels of BMP-3A protein.
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Gene Name:
BMP3
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Protein Name:
Bone morphogenetic protein 3
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Other Name:
BMP3 ;
BMP3A ;
Bone morphogenetic protein 3 ;
BMP-3 ;
Bone morphogenetic protein 3A ;
BMP-3A ;
Osteogenin
BMP3A ;
Bone morphogenetic protein 3 ;
BMP-3 ;
Bone morphogenetic protein 3A ;
BMP-3A ;
Osteogenin
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Database Link:
Background:
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein suppresses osteoblast differentiation, and negatively regulates bone density, by modulating TGF-beta receptor availability to other ligands. [provided by RefSeq, Jul 2016],
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Function:
Function:Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification.,induction:Highly expressed in fracture tissue, particularly in osteoblasts, osteoclasts and chondroblasts.,online information:Bone morphogenetic protein 3 entry,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked.,tissue specificity:Expressed in adult and fetal cartilage.,
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Cellular Localization:
Secreted.
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Tissue Expression:
Expressed in adult and fetal cartilage.
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Research Areas:
>>Cytokine-cytokine receptor interaction
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YT5303
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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