Catalog: YT4873
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
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Main Information
Target
VEGI
Host Species
Rabbit
Reactivity
Human, Rat, Mouse,
Applications
WB, IF, ELISA
MW
20kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:20000; Not yet tested in other applications.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
VEGI Polyclonal Antibody detects endogenous levels of VEGI protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
20kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
Related Products
Primary Antibodies
VEGI Rabbit pAb
YT4873
More→
ELISA Kits
Human TL-1A ELISA Kit
KE1065
More→
ELISA Kits
Total VEGI Cell-Based Colorimetric ELISA Kit
KA3505C
More→
Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human TNFSF15. AA range:181-230
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Specificity:
VEGI Polyclonal Antibody detects endogenous levels of VEGI protein.
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Gene Name:
TNFSF15
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Protein Name:
Tumor necrosis factor ligand superfamily member 15
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Other Name:
TNFSF15 ;
TL1 ;
VEGI ;
Tumor necrosis factor ligand superfamily member 15 ;
TNF ligand-related molecule 1 ;
Vascular endothelial cell growth inhibitor
TL1 ;
VEGI ;
Tumor necrosis factor ligand superfamily member 15 ;
TNF ligand-related molecule 1 ;
Vascular endothelial cell growth inhibitor
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Background:
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011],
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Function:
Function:Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis.,induction:Up-regulated by IL-1-alpha and TNF-alpha.,similarity:Belongs to the tumor necrosis factor family.,subunit:Homotrimer.,tissue specificity:Specifically expressed in endothelial cells. Detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon.,
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Cellular Localization:
Membrane ; Single-pass type II membrane protein .; [Tumor necrosis factor ligand superfamily member 15, secreted form]: Secreted.
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Tissue Expression:
Specifically expressed in endothelial cells. Detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon.
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Research Areas:
>>Cytokine-cytokine receptor interaction
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YT4873
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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