The antiserum was produced against synthesized peptide derived from human UBE2D2. AA range:98-147

UBE2D2 Polyclonal Antibody detects endogenous levels of UBE2D2 protein.

UBE2D2

Ubiquitin-conjugating enzyme E2 D2

UBE2D2 ;
UBC4 ;
UBC5B ;
UBCH4 ;
UBCH5B ;
Ubiquitin-conjugating enzyme E2 D2 ;
Ubiquitin carrier protein D2 ;
Ubiquitin-conjugating enzyme E2 ;
17 ;
KB 2 ;
Ubiquitin-conjugating enzyme E2-17 kDa 2 ;
Ubiquitin-protein ligase D2

Regulated degradation of misfolded, damaged or short-lived proteins in eukaryotes occurs via the ubiquitin (Ub)-proteasome system (UPS). An integral part of the UPS system is the ubiquitination of target proteins and covalent linkage of Ub-containing proteins to form polymeric chains, marking them as targets for 26S proteasome-mediated degradation. Ubiquitination of proteins is mediated by a cascade of enzymes which includes E1 (ubiquitin activating), E2 (ubiquitin conjugating), and E3 (ubiquitin ligases) enzymes. This gene encodes a member of the E2 enzyme family. Substrates of this enzyme include the tumor suppressor protein p53 and peroxisomal biogenesis factor 5 (PEX5). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013],

Catalytic activity:ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.,Function:Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53.,pathway:Protein modification; protein ubiquitination.,similarity:Belongs to the ubiquitin-conjugating enzyme family.,subunit:Interacts with SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex and with E3 ubiquitin-protein ligase PJA2.,

ubiquitin ligase complex,nucleoplasm,cytosol,protein complex,extracellular exosome,

Brain,Cajal-Retzius cell,Testis,

>>Ubiquitin mediated proteolysis ;
>>Protein processing in endoplasmic reticulum ;
>>Shigellosis