Catalog: YT4772
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
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Main Information
Target
TTK
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
WB, IHC, IF, ELISA
MW
100kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000; IF 1:50-200
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
TTK Polyclonal Antibody detects endogenous levels of TTK protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
100kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human TTK. AA range:642-691
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Specificity:
TTK Polyclonal Antibody detects endogenous levels of TTK protein.
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Gene Name:
TTK
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Protein Name:
Dual specificity protein kinase TTK
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Other Name:
TTK ;
MPS1 ;
MPS1L1 ;
Dual specificity protein kinase TTK ;
Phosphotyrosine picked threonine-protein kinase ;
PYT
MPS1 ;
MPS1L1 ;
Dual specificity protein kinase TTK ;
Phosphotyrosine picked threonine-protein kinase ;
PYT
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Background:
TTK protein kinase(TTK) Homo sapiens This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009],
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Function:
Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,Function:Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.,similarity:Contains 1 protein kinase domain.,tissue specificity:Present in rapidly proliferating cell lines.,
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Cellular Localization:
kinetochore,cytoplasm,spindle,membrane,
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Tissue Expression:
Present in rapidly proliferating cell lines.
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Research Areas:
>>Cell cycle
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YT4772
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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