The antiserum was produced against synthesized peptide derived from human TEP1. AA range:171-220

TP1 Polyclonal Antibody detects endogenous levels of TP1 protein.

TEP1

Telomerase protein component 1

TEP1 ;
TLP1 ;
TP1 ;
Telomerase protein component 1 ;
Telomerase-associated protein 1 ;
Telomerase protein 1 ;
p240 ;
p80 telomerase homolog

This gene product is a component of the ribonucleoprotein complex responsible for telomerase activity which catalyzes the addition of new telomeres on the chromosome ends. The telomerase-associated proteins are conserved from ciliates to humans. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016],

Function:Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini. Also component of the ribonucleoprotein vaults particle, a multi-subunit structure involved in nucleo-cytoplasmic transport. Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle. Binds to TERC.,similarity:Contains 1 NACHT domain.,similarity:Contains 1 TROVE domain.,similarity:Contains 21 WD repeats.,similarity:Contains 4 TEP1 N-terminal repeats.,subunit:Component of the telomerase holoenzyme complex at least composed of TERT, DKC1, WDR79/TCAB1, NOP10, NHP2, GAR1, TEP1, EST1A, POT1 and a telomerase RNA template component (TERC). Component of the vault ribonucleoprotein particle, at least composed of MVP, PARP4 and one or more vault RNAs (vRNAs). Binds to VAULTRC1, VAULTRC2 and VAULTRC4/hvg4 vRNAs.,tissue specificity:Ubiquitous.,

Nucleus . Chromosome, telomere.

Ubiquitous.