Catalog: YT4543
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
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Main Information
Target
TAT
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
IHC, IF, ELISA
MW
50kD (Calculated)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
TAT Polyclonal Antibody detects endogenous levels of TAT protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Calculated)
50kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human TAT. AA range:255-304
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Specificity:
TAT Polyclonal Antibody detects endogenous levels of TAT protein.
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Gene Name:
TAT
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Protein Name:
Tyrosine aminotransferase
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Other Name:
TAT ;
Tyrosine aminotransferase ;
TAT ;
L-tyrosine:2-oxoglutarate aminotransferase
Tyrosine aminotransferase ;
TAT ;
L-tyrosine:2-oxoglutarate aminotransferase
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Database Link:
Background:
This nuclear gene encodes a mitochondrial protein tyrosine aminotransferase which is present in the liver and catalyzes the conversion of L-tyrosine into p-hydroxyphenylpyruvate. Mutations in this gene cause tyrosinemia (type II, Richner-Hanhart syndrome), a disorder accompanied by major skin and corneal lesions, with possible mental retardation. A regulator gene for tyrosine aminotransferase is X-linked. [provided by RefSeq, Jul 2008],
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Function:
Catalytic activity:L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate.,cofactor:Pyridoxal phosphate.,Disease:Defects in TAT are the cause of tyrosinemia type 2 (TYRO2) [MIM:276600]; also known as Richner-Hanhart syndrome. TYRO2 is an inborn error of metabolism characterized by elevations of tyrosine in the blood and urine, and oculocutaneous manifestations. Typical features include palmoplantar keratosis, painful corneal ulcers, and mental retardation.,pathway:Amino-acid degradation; L-phenylalanine degradation; acetoacetic acid and fumarate from L-phenylalanine: step 2/6.,similarity:Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.,subunit:Homodimer.,
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Cellular Localization:
mitochondrion,cytosol,
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Tissue Expression:
Liver,
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Research Areas:
>>Ubiquinone and other terpenoid-quinone biosynthesis ;
>>Cysteine and methionine metabolism ;
>>Tyrosine metabolism ;
>>Phenylalanine metabolism ;
>>Phenylalanine, tyrosine and tryptophan biosynthesis ;
>>Metabolic pathways
>>Cysteine and methionine metabolism ;
>>Tyrosine metabolism ;
>>Phenylalanine metabolism ;
>>Phenylalanine, tyrosine and tryptophan biosynthesis ;
>>Metabolic pathways
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Reference Citation({{totalcount}})
Catalog: YT4543
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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