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Catalog: YT3787
Size
Price
Status
Qty.
200μL
$450.00
In stock

0

100μL
$280.00
In stock

0

40μL
$150.00
In stock

0

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Main Information
Target

PLB

Host Species

Rabbit

Reactivity

Human, Mouse, Rat

Applications

WB, IHC, IF

MW

6kD (Calculated)

Conjugate/Modification


Unmodified

Detailed Information
Recommended Dilution Ratio
WB 1:500-2000; IHC 1:50-300; IF 1:200-1:1000;
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
PLB Polyclonal Antibody detects endogenous levels of PLB protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Calculated)
6kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human PLB. AA range:1-50
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Specificity:
PLB Polyclonal Antibody detects endogenous levels of PLB protein.
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Gene Name:
PLN
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Protein Name:
Cardiac phospholamban
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Other Name:
PLN ;
PLB ;
Cardiac phospholamban ;
PLB
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Database Link:
Organism Gene ID SwissProt
Human 5350; P26678;
Mouse 18821; P61014;
Rat 64672; P61016;
Background:
The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy. [provided by RefSeq, Apr 2016],
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Function:
Disease:Defects in PLN are the cause of cardiomyopathy dilated type 1P (CMD1P) [MIM:609909]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.,Function:Phospholamban has been postulated to regulate the activity of the calcium pump of cardiac sarcoplasmic reticulum.,PTM:Phosphorylated in response to beta-adrenergic stimulation.,similarity:Belongs to the phospholamban family.,subunit:Homopentamer.,tissue specificity:Heart.,
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Cellular Localization:
Endoplasmic reticulum membrane ; Single-pass membrane protein . Sarcoplasmic reticulum membrane ; Single-pass membrane protein . Mitochondrion membrane ; Single-pass membrane protein . Membrane ; Single-pass membrane protein . Colocalizes with HAX1 at the endoplasmic reticulum (PubMed:17241641). Colocalizes with DMPK a the sarcoplasmic reticulum (PubMed:15598648). .
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Tissue Expression:
Heart muscle (at protein level).
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Research Areas:
>>Calcium signaling pathway ;
>>cGMP-PKG signaling pathway ;
>>cAMP signaling pathway ;
>>Adrenergic signaling in cardiomyocytes ;
>>Thyroid hormone signaling pathway ;
>>Dilated cardiomyopathy ;
>>Diabetic cardiomyopathy
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Catalog: YT3787
Size
Price
Status
Qty.
200μL
$450.00
In stock

0

100μL
$280.00
In stock

0

40μL
$150.00
In stock

0

Add to cart

Collected

Collect

Customized Service

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