The antiserum was produced against synthesized peptide derived from human PARD6B. AA range:233-282

PAR-6β Polyclonal Antibody detects endogenous levels of PAR-6β protein.

PARD6B

Partitioning defective 6 homolog beta

PARD6B ;
PAR6B ;
Partitioning defective 6 homolog beta ;
PAR-6 beta ;
PAR-6B

This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain, an OPR domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cytoplasmic protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. [provided by RefSeq, Jul 2008],

Domain:The PDZ domain mediates interaction with MPP5.,Domain:The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases.,Function:Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins.,similarity:Belongs to the PAR6 family.,similarity:Contains 1 OPR domain.,similarity:Contains 1 PDZ (DHR) domain.,similarity:Contains 1 pseudo-CRIB domain.,subunit:Interacts with PARD3. Interacts with GTP-bound forms of CDC42 and RAC1. Interacts with GTP-bound ARHQ/TC10. Interacts with MPP5 (By similarity). Interacts with the N-terminal part of PRKCI and PRKCZ. Part of a complex with PARD3, CDC42 or RAC1 and PRKCI or PRKCZ. Part of a complex with LLGL1 and PRKCI. Interacts with ALS2CR19.,tissue specificity:Expressed in pancreas and in both adult and fetal kidney. Weakly expressed in placenta and lung. Not expressed in other tissues.,

Cytoplasm. Cell membrane . Cell junction, tight junction .

Expressed in pancreas and in both adult and fetal kidney. Weakly expressed in placenta and lung. Not expressed in other tissues.

>>Rap1 signaling pathway ;
>>Endocytosis ;
>>Axon guidance ;
>>Hippo signaling pathway ;
>>Tight junction ;
>>Human papillomavirus infection