Catalog: YT2783
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
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0
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Main Information
Target
MLK1
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
IHC, IF, ELISA
MW
122kD (Calculated)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
IHC 1:100-1:300; ELISA 1:20000; IF 1:50-200
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
MLK1 Polyclonal Antibody detects endogenous levels of MLK1 protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Calculated)
122kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human MAP3K9. AA range:561-610
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Specificity:
MLK1 Polyclonal Antibody detects endogenous levels of MLK1 protein.
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Gene Name:
MAP3K9
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Protein Name:
Mitogen-activated protein kinase kinase kinase 9
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Other Name:
MAP3K9 ;
MLK1 ;
PRKE1 ;
Mitogen-activated protein kinase kinase kinase 9 ;
Mixed lineage kinase 1
MLK1 ;
PRKE1 ;
Mitogen-activated protein kinase kinase kinase 9 ;
Mixed lineage kinase 1
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Background:
MAP3K9 (Mitogen-Activated Protein Kinase Kinase Kinase 9) is a Protein Coding gene. Diseases associated with MAP3K9 include retroperitoneal neuroblastoma. Among its related pathways are MAP Kinase Signaling andTGF-Beta Pathway. GO annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is KSR1.
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Function:
Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Homodimerization via the leucine zipper domains is required for autophosphorylation and subsequent activation.,Function:Activates the JUN N-terminal pathway.,PTM:Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation. Thr-312 is likely to be the main autophosphorylation site.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH3 domain.,subunit:Homodimer.,tissue specificity:Expressed in epithelial tumor cell lines of colonic, breast and esophageal origin.,
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Cellular Localization:
intracellular,integral component of membrane,
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Tissue Expression:
Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YT2783
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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