The antiserum was produced against synthesized peptide derived from human MINPP1. AA range:328-377

MIPP Polyclonal Antibody detects endogenous levels of MIPP protein.

MINPP1

Multiple inositol polyphosphate phosphatase 1

MINPP1 ;
MIPP ;
Multiple inositol polyphosphate phosphatase 1 ;
2 ;
3-bisphosphoglycerate 3-phosphatase ;
2,3-BPG phosphatase ;
Inositol ;
1,3,4,5 ;
-tetrakisphosphate 3-phosphatase ;
Ins ;
1,3,4,5 ;
P ;
4 ;
3-phosphatase

This gene encodes multiple inositol polyphosphate phosphatase; an enzyme that removes 3-phosphate from inositol phosphate substrates. It is the only enzyme known to hydrolzye inositol pentakisphosphate and inositol hexakisphosphate. This enzyme also converts 2,3 bisphosphoglycerate (2,3-BPG) to 2-phosphoglycerate; an activity formerly thought to be exclusive to 2,3-BPG synthase/2-phosphatase (BPGM) in the Rapoport-Luebering shunt of the glycolytic pathway.[provided by RefSeq, Sep 2009],

Catalytic activity:Myo-inositol hexakisphosphate + H(2)O = myo-inositol pentakisphosphate (mixed isomers) + phosphate.,Disease:Defects in MINPP1 may be involved in follicular thyroid tumors development.,Function:Acts as a phosphoinositide 5- and phosphoinositide 6-phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6) (By similarity). May play a role in bone development (endochondral ossification).,tissue specificity:Widely expressed with highest levels in kidney, liver and placenta.,

Endoplasmic reticulum lumen .

Widely expressed with highest levels in kidney, liver and placenta.

>>Glycolysis / Gluconeogenesis ;
>>Inositol phosphate metabolism ;
>>Metabolic pathways