The antiserum was produced against synthesized peptide derived from human ACTHR. AA range:248-297

MC2-R Polyclonal Antibody detects endogenous levels of MC2-R protein.

MC2R

Adrenocorticotropic hormone receptor

MC2R ;
ACTHR ;
Adrenocorticotropic hormone receptor ;
ACTH receptor ;
ACTH-R ;
Adrenocorticotropin receptor ;
Melanocortin receptor 2 ;
MC2-R

MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency. Alternate transcript variants have been found for this gene. [provided by RefSeq, May 2014],

Disease:Defects in MC2R are the cause of glucocorticoid deficiency type 1 (GCCD1) [MIM:202200]; also known as familial glucocorticoid deficiency type 1 (FGD1). GCCD1 is an autosomal recessive disorder due to congenital insensitivity or resistance to adrenocorticotropin (ACTH). It is characterized by progressive primary adrenal insufficiency, without mineralocorticoid deficiency.,Function:Receptor for ACTH. This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with FALP/MRAP.,tissue specificity:Melanocytes and corticoadrenal tissue.,

Cell membrane; Multi-pass membrane protein.

Melanocytes and corticoadrenal tissue.

>>cAMP signaling pathway ;
>>Neuroactive ligand-receptor interaction ;
>>Aldosterone synthesis and secretion ;
>>Cortisol synthesis and secretion ;
>>Cushing syndrome