Synthesized peptide derived from MAN1B1 . at AA range: 100-180

MAN1B1 Polyclonal Antibody detects endogenous levels of MAN1B1 protein.

MAN1B1

Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase

MAN1B1 ;
Endoplasmic reticulum mannosyl-oligosaccharide 1 ;
2-alpha-mannosidase ;
ER alpha-1,2-mannosidase ;
ER mannosidase 1 ;
ERMan1 ;
Man9GlcNAc2-specific-processing alpha-mannosidase ;
Mannosidase alpha class 1B member 1

This gene encodes an enzyme belonging to the glycosyl hydrolase 47 family. This enzyme functions in N-glycan biosynthesis, and is a class I alpha-1,2-mannosidase that specifically converts Man9GlcNAc to Man8GlcNAc isomer B. It is required for N-glycan trimming to Man5-6GlcNAc2 in the endoplasmic-reticulum-associated degradation pathway. Mutations in this gene cause autosomal-recessive intellectual disability. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 11. [provided by RefSeq, Dec 2011],

Catalytic activity:Hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2).,cofactor:Calcium.,enzyme regulation:Inhibited by both 1-deoxymannojirimycin and kifunensine.,Function:Involved in the maturation of Asn-linked oligosaccharides. Trim a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2). The only product is the Man(8)GlcNAc(2) isomer B, the form lacking the middle-arm terminal alpha 1,2-mannose. It may be involved in glycoprotein quality control since it is important to target misfolded glycoproteins for degradation.,pathway:Protein modification; protein glycosylation.,similarity:Belongs to the glycosyl hydrolase 47 family.,tissue specificity:Widely expressed.,

Endoplasmic reticulum membrane ; Single-pass type II membrane protein .

Widely expressed.

>>N-Glycan biosynthesis ;
>>Various types of N-glycan biosynthesis ;
>>Metabolic pathways ;
>>Protein processing in endoplasmic reticulum