Catalog: YT2558
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
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Main Information
Target
LHR
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IF, ELISA, IHC
MW
80kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000; IHC 1:50-300; IF 1:200-1:1000; ELISA 1:2000-20000
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
LHR Polyclonal Antibody detects endogenous levels of LHR protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
80kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human LSHR. AA range:621-670
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Specificity:
LHR Polyclonal Antibody detects endogenous levels of LHR protein.
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Gene Name:
LHCGR LCGR LGR2 LHRHR
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Protein Name:
Lutropin-choriogonadotropic hormone receptor
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Other Name:
LHCGR ;
LCGR ;
LGR2 ;
LHRHR ;
Lutropin-choriogonadotropic hormone receptor ;
LH/CG-R ;
Luteinizing hormone receptor ;
LHR ;
LSH-R
LCGR ;
LGR2 ;
LHRHR ;
Lutropin-choriogonadotropic hormone receptor ;
LH/CG-R ;
Luteinizing hormone receptor ;
LHR ;
LSH-R
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Database Link:
Background:
This gene encodes the receptor for both luteinizing hormone and choriogonadotropin. This receptor belongs to the G-protein coupled receptor 1 family, and its activity is mediated by G proteins which activate adenylate cyclase. Mutations in this gene result in disorders of male secondary sexual character development, including familial male precocious puberty, also known as testotoxicosis, hypogonadotropic hypogonadism, Leydig cell adenoma with precocious puberty, and male pseudohermaphtoditism with Leydig cell hypoplasia. [provided by RefSeq, Jul 2008],
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Function:
Alternative products:Additional isoforms seem to exist,Disease:Defects in LHCGR are a cause of familial male precocious puberty (FMPP) [MIM:176410]; also known as testotoxicosis. In FMPP the receptor is constitutively activated.,Disease:Defects in LHCGR are a cause of Leydig cell hypoplasia (LCH) [MIM:152790]. LCH is an autosomal recessive disease characterized by male pseudohermaphroditism. In LCH the testes are small with marked immaturity of the Leydig cells which correlates with undetectable plasma testosterone levels and elevated gonadotropins.,Function:Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.,online information:Glycoprotein-hormone Receptors Information System,similarity:Belongs to the G-protein coupled receptor 1 family.,similarity:Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.,similarity:Contains 7 LRR (leucine-rich) repeats.,tissue specificity:Gonadal and thyroid cells.,
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Cellular Localization:
Cell membrane ; Multi-pass membrane protein .
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Tissue Expression:
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Research Areas:
>>Calcium signaling pathway ;
>>cAMP signaling pathway ;
>>Neuroactive ligand-receptor interaction ;
>>Ovarian steroidogenesis ;
>>Prolactin signaling pathway
>>cAMP signaling pathway ;
>>Neuroactive ligand-receptor interaction ;
>>Ovarian steroidogenesis ;
>>Prolactin signaling pathway
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YT2558
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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