The antiserum was produced against synthesized peptide derived from human IPPK. AA range:11-60

InsP5 2-kinase Polyclonal Antibody detects endogenous levels of InsP5 2-kinase protein.

IPPK

Inositol-pentakisphosphate 2-kinase

IPPK ;
C9orf12 ;
Inositol-pentakisphosphate 2-kinase ;
IPK1 homolog ;
Inositol-1 ;
3,4,5,6-pentakisphosphate 2-kinase ;
Ins ;
1,3,4,5,6 ;
P5 2-kinase ;
InsP5 2-kinase

The protein encoded by this gene is a kinase that phosphorylates position 2 of inositol-1,3,4,5,6-pentakisphosphate to form inositol-1,2,3,4,5,6-hexakisphosphate (InsP6). InsP6 has a variety of functions, including stimulation of DNA repair, endocytosis, and mRNA export. [provided by RefSeq, Nov 2010],

Catalytic activity:ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol hexakisphosphate.,Domain:The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.,Function:Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis.,similarity:Belongs to the IPK1 type 2 family.,tissue specificity:Ubiquitously expressed, with high expression in heart, brain, testis and placenta.,

Cytoplasm . Nucleus .

Ubiquitously expressed, with high expression in heart, brain, testis and placenta.

>>Inositol phosphate metabolism ;
>>Metabolic pathways ;
>>Phosphatidylinositol signaling system