Synthesized peptide derived from EphA3 . at AA range: 540-620

EphA3 Polyclonal Antibody detects endogenous levels of EphA3 protein.

EPHA3

Ephrin type-A receptor 3

EPHA3 ;
ETK ;
ETK1 ;
HEK ;
TYRO4 ;
Ephrin type-A receptor 3 ;
EPH-like kinase 4 ;
EK4 ;
hEK4 ;
HEK ;
Human embryo kinase ;
Tyrosine-protein kinase TYRO4 ;
Tyrosine-protein kinase receptor ETK1 ;
Eph-like tyrosine kinase 1

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008],

Catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,Disease:Defects in EPHA3 may be a cause of colorectal cancer (CRC) [MIM:114500].,Function:Receptor for members of the ephrin-A family. Binds to ephrin-A2, -A3, -A4 and -A5. Could play a role in lymphoid function.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,similarity:Contains 2 fibronectin type-III domains.,tissue specificity:Widely expressed. Highest level in placenta.,

[Isoform 1]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 2]: Secreted .

Widely expressed. Highest level in placenta.

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