Catalog: YT1430
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
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Collected
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Main Information
Target
Dynein IC2
Host Species
Rabbit
Reactivity
Human, Mouse, Rat, Chicken
Applications
WB, ELISA
MW
70kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
Dynein IC2 Polyclonal Antibody detects endogenous levels of Dynein IC2 protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
70kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human DNAI2. AA range:71-120
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Specificity:
Dynein IC2 Polyclonal Antibody detects endogenous levels of Dynein IC2 protein.
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Gene Name:
DNAI2
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Protein Name:
Dynein intermediate chain 2 axonemal
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Other Name:
DNAI2 ;
Dynein intermediate chain 2 ;
axonemal ;
Axonemal dynein intermediate chain 2
Dynein intermediate chain 2 ;
axonemal ;
Axonemal dynein intermediate chain 2
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Database Link:
Background:
The protein encoded by this gene belongs to the dynein intermediate chain family, and is part of the dynein complex of respiratory cilia and sperm flagella. Mutations in this gene are associated with primary ciliary dyskinesia type 9. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Mar 2010],
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Function:
Disease:Defects in DNAI2 are the cause of primary ciliary dyskinesia type 9 (CILD9) [MIM:612444]. CILD is an autosomal recessive disorder characterized by axonemal abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit situs inversus, due to dysfunction of monocilia at the embryonic node and randomization of left-right body asymmetry. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome.,Function:Part of the dynein complex of respiratory cilia.,sequence Caution:Intron retention.,similarity:Belongs to the dynein intermediate chain family.,similarity:Contains 5 WD repeats.,subunit:Consists of at least two heavy chains and a number of intermediate and light chains. Interacts with KTU.,tissue specificity:Highly expressed in trachea and testis.,
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Cellular Localization:
Cytoplasm, cytoskeleton, cilium axoneme . Dynein axonemal particle . Located in the proximal region of respiratory cilia. .
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Tissue Expression:
Research Areas:
>>Amyotrophic lateral sclerosis ;
>>Huntington disease ;
>>Pathways of neurodegeneration - multiple diseases
>>Huntington disease ;
>>Pathways of neurodegeneration - multiple diseases
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YT1430
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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