Catalog: YT1153
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
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Main Information
Target
CTPS
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, IF, ELISA
MW
67kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000; IF 1:50-200
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
CTPS Polyclonal Antibody detects endogenous levels of CTPS protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
67kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human CTPS. AA range:60-109
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Specificity:
CTPS Polyclonal Antibody detects endogenous levels of CTPS protein.
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Gene Name:
CTPS1
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Protein Name:
CTP synthase 1
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Other Name:
CTPS1 ;
CTPS ;
CTP synthase 1 ;
CTP synthetase 1 ;
UTP--ammonia ligase 1
CTPS ;
CTP synthase 1 ;
CTP synthetase 1 ;
UTP--ammonia ligase 1
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Background:
This gene encodes an enzyme responsible for the catalytic conversion of UTP (uridine triphosphate) to CTP (cytidine triphospate). This reaction is an important step in the biosynthesis of phospholipids and nucleic acids. Activity of this proten is important in the immune system, and loss of function of this gene has been associated with immunodeficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014],
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Function:
Catalytic activity:ATP + UTP + NH(3) = ADP + phosphate + CTP.,enzyme regulation:Activated by GTP and inhibited by CTP.,Function:Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.,pathway:Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.,similarity:Belongs to the CTP synthase family.,similarity:Contains 1 glutamine amidotransferase type-1 domain.,
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Cellular Localization:
Cytoplasm, cytosol . Mainly cytosolic but when active detected in long filamentous structures (PubMed:25223282). Co-localizes with TNK2 in the cytosolic filaments (By similarity). .
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Tissue Expression:
Widely expressed.
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Research Areas:
>>Pyrimidine metabolism ;
>>Metabolic pathways ;
>>Nucleotide metabolism ;
>>Biosynthesis of cofactors
>>Metabolic pathways ;
>>Nucleotide metabolism ;
>>Biosynthesis of cofactors
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Reference Citation({{totalcount}})
Catalog: YT1153
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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